Cubis II Ultra-High Resolution Balances The New Benchmark in Performance Uncompromized Accuracy and High Speed Under Real Laboratory Conditions

The characteristics of a high resolution laboratory balance are that they have a high weighing capacity and fine readability. This type of analytical instrument is used to weigh very small sample quantities directly into larger flasks. It is broadly used across many industries, such as pharmaceutical, biopharmaceutical, chemical, environmental, automotive or medical devices industries, as well as in academia. Most of these industries are subject to strict legal regulations and are looking for balances which meet the requirements for high accuracy and repeatability over the entire weighing range. However, challenging laboratory environments or effects deriving from samples often negatively impact the measurement accuracy.

The Cubis® II Ultra-High Resolution Balance is a new addition to our Cubis® II portfolio of premium laboratory balances. It offers the well know signature characteristics of the Cubis® II family: modularity, compliance, connectivity and digital data management either by directly connecting to ELN/LIMS on site or indirectly through the Ingenix Suite. Additionally, these balances are less prone to environmental effects, resulting in faster weighing workflows and improved performance in a daily laboratory environment. The balances offer spacious weighing area despite a compact design which supports ergonomic weighing into various flasks. We brought cleanability to the next level as well. Not only easy disassembly and high chemical resistance is guaranteed, but thanks to the new Cleaning App, the cleaning process can become part of compliance and SOP´s. We also made sure that the new balances are worth the investment, we offer the option to upgrade both the software and hardware of your instrument at a later stage, minimizing your upfront costs.

• Minimizing sample costs by excellent minimum sample weight values through the entire weighing range
• Faster results and improved specifications guaranteed by the new weighing system
• 21CFR part 11 and EU Annex 11 compliance, all controls available directly on your balance
• Intuitive cleaning, high chemical resistance. Thanks to the Cleaning App the cleaning is now part of compliance and SOPs
• 100% discharged samples thanks to the novel ionizing technology guarantees fast stabilization
• Touch free operation minimizes cross-contamination
• 66% larger weighing area and variety of weighing pans offer ergonomic sample weighing
• Investment security thanks to the post-purchase hardware and software upgradeability
• Choose from the following high-capacity microbalances:
• 1 microgram readability up to 61g capacity (Models: 66S/P, 36S/P)
• 2 microgram readability up to 111 g capacity (Model 116S)

Real lab performance often deviates from instrument specifications due to varying environmental conditions, such as changes in temperature, air-pressure, humidity or air-draft change. Samples can also be influenced, as well, e.g. problems with static charges are frequent when weighing powder compounds directly into plastic- or glass flasks. Despite these influencing factors, it needs to be ensured that a high-resolution device still meets the requirements for accuracy and repeatability.

The new Cubis® II Ultra-High Resolution Balances help to manage the challenges from a typical laboratory environment thanks to its innovative design elements. The 4th generation Monolith, invented by Sartorius, allows faster weighing results and improves specification. Hence, high degree of repeatability and fast measurement time is to be expected when working with these devices. Built-in intelligent compensating systems manage temperature-, humidity- and air pressure changes which further ensure stable balance behavior. The optimal positioning of the four ionizing nozzles and the technology behind it guarantees complete electrostatic elimination. Find out more about how these balances perform under drafty conditions and in typical lab environment in our App Note: Cubis® II Ultra-High Resolution Balances: From Data Sheet to Reality

High resolution and high-capacity instruments allow weighing very small amounts of samples into large flasks. Expectations to achieve low minimum sample weights for these devices are high. However, the smaller the weight of the sample, the larger the relative measurement uncertainty that the weighing is subject to. The measurement uncertainty can be greatly influenced by environmental changes occurring in laboratories.

The Cubis® II High-Capacity Microbalance ensures stable and reliable performance over the entire weighing range thanks to the design elements described previously. Repeatability values with low measurement uncertainty can be achieved over the entire weighing range, resulting in low minimum sample weight. This minimizes the cost of samples. Find out more about the test results of minimum sample weight valus using various protocols according to USP in our App Note: Cubis® II Ultra-High Resolution Balances: From Data Sheet to Reality

Industries depend on strict legal regulations and follow the US or European Pharmacopoeias. The Pharma QApp Package (QP1) of the Cubis® II MCA offers applications which are needed to comply with pharmaceutical-relevant guidelines such as 21 CFR Part 11 and USP 39, Chapter 41. It includes: user management, electronic signature, audit trail, minimum weight, USP advanced, measurement uncertainty, and user calibration.

To support ergonomic weighing processes, both the weighing pan size and the inner weighing area was significantly increased allowing easy handling of samples and flasks. However, while standard weighing pans are the most used surfaces during the typical weighing processes, they reach their limit as soon as samples with a unique form or vials and flasks need to be used. Also, a too small/narrow inner area can make some of these weighing processes uncomfortable or even impossible.

A great variety of sample holders are available which enable ergonomic sample weighing in workflows where using a standard pan is difficult or impossible. All weighing pans and sample holders are made of titanium, which ensure uncompromised accuracy due to its non-magnetic properties.

Including cleaning oas part of an analytical balance is often neglected, despite the chance of cross-contamination when uncleaned regularly and properly. The higher the resolution, the greater the risk, because even a small particle can negatively impact the weighing accuracy. Despite this, only 28% of laboratories clean their high resolution analytical devices on a daily basis according to users. Often it is unclear which parts can be removed for cleaning, or it is unclear which chemicals are good to use.

All draft-shields, including the front-shield, as well as the weighing pans and the base plate, can be easily removed allowing a tool free assembly. Both the weighing floor and the weighing pan show high chemical resistance against the most frequently used cleaning agents in the laboratory. The inner weighing system is protected thanks to the high volume capacity and the design of the weighing floor. The cleaning kit, which comes with every balance, includes useful tools such as hard and soft brushes, dry cloth and forceps, helping to make weighing workflows faster.

Follow the steps in the new cleaning QApp for error free cleaning execution. It supports your daily and advanced cleaning routines, shows the cleaning status in the status center and allows tracing the cleaning process in the audit trail. The Cleaning QApp is configurable with user management allowing the documentation of inclusive electronic signature, and comes standard with every MCA Ultra-High Resolution Balance. Find out more cleaning in Best Cleaning Practices.

• Daily and Advanced Cleaning
• Guided Cleaning Process adapted to your balance configuration
• Traceable documentation in audit trail
• Cleaning status shown in the status center

Sometimes it is difficult to predict, what kind of challenge will you be facing in the future. Is the humidity in your facility too low, or your samples are prone to static charges, but you don´t have an ionizer? Or wish you had an auto-draftshield but you already purchased your balance?

• QP1 Pharma - Contains applications concerning the topic of compliance with pharmaceutical-relevant guidelines as 21 CFR Part 11 and USP 39, Chapter 41. The Pharma package includes applications such as user management, digital signatures, audit trail, USP minimum weight.
• QP2 Advanced Applications - Various complex weighing applications including evaluation. This includes applications used for density determination, percentage weighing, counting, backweighing, residual dirt analysis, residue on ignition, sieve analysis, filter weighing, checkweighing, formulation, averaging, etc.
• QP3 Utilities - Contains weighing applications and function extensions such as bootscreen, color scheme, free formula, fiber coarseness, diameter determination, air buyoancy correction, paper weight, statistics and printing of QR | bar codes
• QP4 Connectivity - Includes applications for data exchange; for example to Windows file server, FTPS, StarLims, etc.
• QP99 - All inclusive package. Includes 4 different sub-packages for compliance (Pharma (QP1)), complex weighing applications (Advanced (QP2)), weighing applications and helpful tools (Utilities (QP3)) and connectors for data exchange (Connectivity (QP4)).

• Ultra-high resolution with up to 61 million weighing steps (digits)
• End-to-end data integrity. 21 CFR Part 11 compliance, integrated audit-trail, state-of-the-art user management
• Cleanability, part of compliance
• Error-free operation. Individual QApp workflows, motorized auto-leveling
• Allow upgrades for hardware features like automated draft shields or built-in ionizer
• Optional inner draft shield for best weighing performance

The Cubis® II laboratory balances are modular, therefore they allow to choose between applications and configurations which suit the best to the needs. These balances can be configured at the level of display, draftshields, software applications and hardware functions. The Cubis® II range of high-capacity micro balances with a maximum load between 32 g and 111 g and a readability between 0.001 mg and 0.002 mg provide the ideal choice for a broad range of applications.